News & events

At the beginning of this year, part of the SiMBiT consortium published a paper on current development regarding innovative sensors technique: “Organic Field-Effect Transistor Platform for Label-Free, Single-Molecule Detection of Genomic Biomarkers” Eleonora Macchia, Kyriaki Manoli, Cinzia Di Franco, Rosaria Anna Picca, Ronald Österbacka, Gerardo Palazzo, Fabrizio Torricelli, Gaetano Scamarcio, and Luisa Torsi, ACS Sensors 2020 5 (6), 1822-1830

Discover the published paper using the following link!


Short abstract :

The rising interest for technologies capable to track a biomarker down to the physical limit points towards new opportunities in early diagnostics of progressive diseases. Electrolyte-gated field-effect transistors, also addressed as Single-Molecule with a large Transistors (SiMoT), represent an extremely powerful tool to achieve label-free and single-molecule detection of clinically relevant biomarkers. In this study, for the first time, the SiMoT sensing response towards genomic biomarker for multiple sclerosis (miR-182) is proposed. This is relevant, not only because single molecule detection limits are demonstrated, but also because it proves that the SiMoT label-free single molecule detection principle is the only one of his kind that can detect, by means of the same platform, both protein and genomic markers.

 

Already 14 months have passed since the beginning of the SiMBiT project. Now that the first year of the project is over, it is time to introduce what has been achieved so far by all the partners of the project:

  • Set-up of the product’s specifications, common procedures and protocols so all SiMBiT’s activities are following same procedures to comply with future certification activities
  • Work on the design and the characterization of the semiconductor and the EG-TFT especially the design of the gate (figure 1). Physical and electrical characteristics as well as transistors’ stability in water were studied ( figure 2).
    2020 03 11 FIG1  2020 03 11 FIG2
    Figure 1 : Scheme and picture of the set-up used for studying EG-TFT devices   Figure 2 : Modelling of P3HT degradation over 7 days, expressed as ID(max) vs time. In the inset, the shift in the threshold voltage is also modelled with the same function

 

  • Work design of the final prototype with a first step completed: the first prototype for the 4x4 well array
  • Set-up and start of the collection of biologic samples
  • Screening for additional biomarkers by miRNA identification
  • Dissemination with 14 scientific publications and participation to 24 European and international events
 If you want to find out more about SiMBiT first-year activities, you can consult our “publishable technical early progress report”
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On the 20th and the 21st June 2019, all partners of the SiMBiT project gathered together for the second time for our 2nd executive board and 1st steering committee. The event was organized by SiMBiT partner The University of Brescia, in Brescia and at the Garde Lake in Italy.

The technical part of the meeting showed that the project is currently moving forward according to our GANTT Chart.

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This European workshop presents breakthroughs and innovations in smart bioelectronics and flexible & wearable systems with the presence of market leaders, innovators, researchers, professional and user organisations. The goal is to raise the importance of electronics and in particular smart integrated sensor systems using heterogeneous technologies, new materials and fabrication processes.

Professor Luisa Torsi and her team (CSGI @ Università degli Studi di Bari Aldo Moro) will attend to both days workshop and will present the SiMBiT project on the second day (October 23rd) at 14:50.

Find further information and the complete programme here : https://ec.europa.eu/digital-single-market/en/news/workshop-smart-bioelectronic-and-wearable-systems

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We were happy to present SiMBiT project at the 37th E-MRS congress holding in Nice this end of May. Pr Luisa Torsi from the University of Bari – CSGI and her team and Dr Fabrizio Torricelli from University of Brescia Department of Information Engineering were at the congress to talk about the development of our single molecule bio-electronic smart assay system.

The European Materials Research Society (E-MRS) highlight the latest advances in materials research at an international level organized into 6 topical clusters and more than 80 exhibitors:

  • Materials for Energy
  • Bio- and Soft Materials
  • Nano-functional Materials
  • 2 Dimensional Materials
  • Materials, Electronics and Photonics
  • Modelling and Characterization