At the beginning of this year, part of the SiMBiT consortium published a paper on current development regarding innovative sensors technique: “Organic Field-Effect Transistor Platform for Label-Free, Single-Molecule Detection of Genomic Biomarkers” Eleonora Macchia, Kyriaki Manoli, Cinzia Di Franco, Rosaria Anna Picca, Ronald Österbacka, Gerardo Palazzo, Fabrizio Torricelli, Gaetano Scamarcio, and Luisa Torsi, ACS Sensors 2020 5 (6), 1822-1830
Discover the published paper using the following link!
Short abstract :
The rising interest for technologies capable to track a biomarker down to the physical limit points towards new opportunities in early diagnostics of progressive diseases. Electrolyte-gated field-effect transistors, also addressed as Single-Molecule with a large Transistors (SiMoT), represent an extremely powerful tool to achieve label-free and single-molecule detection of clinically relevant biomarkers. In this study, for the first time, the SiMoT sensing response towards genomic biomarker for multiple sclerosis (miR-182) is proposed. This is relevant, not only because single molecule detection limits are demonstrated, but also because it proves that the SiMoT label-free single molecule detection principle is the only one of his kind that can detect, by means of the same platform, both protein and genomic markers.